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Are you trying to find out where the San Francisco Giants play? Here we will not only tell you what city and state the San Francisco Giants play in. We'll also tell you what league the San Francisco Giants play in, and in what home park the San Francisco Giants play their home games. The San Francisco Giants play in the National League of the Major League Baseball (MLB). The hometown of the San Francisco Giants is San Francisco, California. Furthermore, the home park of the San Francisco Giants is the AT&T Park. Professional Sports Team Locations Go here if you need to find the location of another professional sports team.